What is Reconcile (Fluoxetine)?
Containing Fluoxetine, Reconcile is a product designed to support the management of reactive or anxious behaviours in dogs, especially those prone to separation-related issues. You might recognise the name Fluoxetine as the generic version of Prozac, a medication that is widely used to treat anxiety and depression in humans. Reconcile is a veterinary formulation of the same drug, designed specifically for dogs. Reconcile is intended to be part of a comprehensive treatment plan, addressing behaviours such as excessive barking, general anxiousness and fear, and inappropriate toileting.
Fluoxetine belongs to a class of drugs known as selective serotonin reuptake inhibitors (SSRIs), which function by increasing the levels of serotonin in the brain. Serotonin, frequently called the "feel-good" neurotransmitter, plays an important role in regulating mood, sleep, appetite, and various other bodily functions. When serotonin levels are increased, especially in a controlled and balanced way, it can have several positive effects.
While Reconcile doesn’t “fix” behavioural issues on its own, it can take the edge off for dogs whose anxiety or over-reactivity is getting in the way of their ability to learn and cope with the world around them.

How Reconcile Can Help Reactive Dogs
Reconcile isn’t a magic wand for curing reactivity in dogs, but it can make a world of difference for certain pups. By balancing serotonin levels, Fluoxetine helps lower a dog’s baseline anxiety. When our dog feels calmer, they’re better able to focus and engage in training exercises. This is particularly important for reactive dogs, where fear-based reactivity or overstimulation often blocks their ability to think clearly.
For example, most of us dealing with reactive dogs will understand the experience of our pup barking and lunging at every person or dog that we pass on the street. With Reconcile, that same dog may feel less anxious, making it easier to redirect their focus towards us as handlers, so that we can reward calm behaviour.
It's important to understand that Reconcile doesn't work overnight, or even at all. Most dogs will take about four to six weeks to show improvements on Reconcile, while some can take a handful of months as the medication builds up in their system. In the meantime, pairing medication with consistent training is critical to seeing long-term results.
The Process of Using Reconcile in the United Kingdom
If you believe Reconcile might help your dog, the first step is to talk to your veterinarian. They’ll assess your pup's health, behaviour, and specific triggers before prescribing the medication. Here’s what to expect:
- Veterinary Evaluation: Your vet will look for underlying medical issues that could contribute to reactivity, such as thyroid problems or chronic pain. You will likely be referred to a veterinarian behaviourist who will conduct additional evaluations and may also prescribe painkillers for some time to rule out pain-induced reactivity. If you are already working with a professional behaviourist and believe Reconcile may be appropriate, discuss this option with your behaviourist and ask them for a letter of recommendation to be sent to your veterinarian.
- Dosage Plan: Once other options have been explored, your veterinarian will look into behavioural medications. You may find that other options will be recommended before Reconcile, such as Trazadone. However, at this stage, your vet will prescribe a dosage that is tailored to your dog’s size, weight, and needs. You should never adjust the dose on your own.
- Monitoring: Your vet will likely schedule follow-ups to track progress and adjust the medication if needed.
It’s also essential to combine Reconcile with a structured behavioural plan. Think of the medication as a tool to open the door for learning—not the sole solution.
Benefits of Reconcile for Reactive Dogs
So, what kind of changes can you expect? Here are some of the most commonly reported benefits:
- Calmer Responses to Triggers: Dogs on Reconcile may become less reactive to their specific triggers, whether it’s other dogs, strangers, or loud noises.
- Improved Focus: With their anxiety dialled down, your pup may be better able to concentrate on training cues and commands.
- Reduced Fearfulness: Many owners report their dogs seeming more relaxed overall, even in situations that previously caused extreme stress.
Of course, every dog is different, and results can vary. The key is patience - medication is a process, not a quick fix.

Potential Side Effects and Challenges
As with any medication, Reconcile comes with potential side effects. Most are mild and temporary, but it’s important to know what to watch for. Common side effects include:
- Lethargy or drowsiness
- Changes in appetite (either increased or decreased)
- Upset stomach or diarrhoea
In rare cases, some dogs may experience heightened anxiety or even aggression. Many owners have reported that during the loading period (particularly around 3-5 weeks) their pup had heightened reactivity, that eventually subsided. If you notice any concerning changes, call your vet immediately - they may need to adjust the dosage or explore alternative options.
Another challenge is the adjustment period. While the medication takes time to work, you may not see results right away. During this period, it’s essential to stick with your training routine and communicate closely with your vet.
Success Stories
Hearing about other dogs’ experiences can be incredibly reassuring. Take, for example, this post regarding a pup's Reconcile journey:
"Our last couple of walks have been so good I could scream with joy. She is no longer over-aroused with just going outside. Today was a perfect fall day, and we had a great walk with a ton of sniffing, 98% loose leash, and dismissing other dogs. All of my training for the last year is finally paying off. I 100% believe it was her brain/nervous system holding her back from just… existing normally."
For another owner, this is what they reported during their pup's 8-week journey on Fluoxetine:
"Over the last 8 weeks, we have started slowly seeing the positive effects of this medication. I am forever grateful to everyone who suggested this and encouraged me to talk to our vet. This has given us a renewed outlook on life and if I could hug all of you... I absolutely would. Over the last 2 weeks, we have TRULY seen a difference in our boy. He is so much more willing to redirect. I have a much better chance of redirecting before the reaction... Training is so much more manageable and he is able to THINK. He is more neutral in situations he normally would lose it in... And he is just so much more HAPPY!"
Alternatives and Complementary Approaches
Medication isn’t the only solution for reactive dogs, and it’s not the right choice for everyone. Here are some other tools and techniques that can work alongside, or instead of, Reconcile:
- Behavioural Training: Techniques like counter-conditioning and desensitisation are essential for addressing the root cause of reactivity.
- Supplements: Natural remedies like calming chews or CBD oil may help mild cases of anxiety.
- Environmental Adjustments: Providing safe spaces, using noise machines, or adjusting your dog’s daily routine can reduce stress triggers.
The best approach is often a combination of strategies tailored to your dog’s unique needs. It's important to remember that it can take a combination of techniques to help your pup feel comfortable and confident.
Conclusion
Reconcile (Fluoxetine) is a valuable tool for managing canine reactivity, especially when paired with training and a solid behavioural plan. While it’s not a one-size-fits-all solution, it can significantly improve the quality of life for both dogs and us as owners. If you’re feeling overwhelmed by your dog’s behaviour, know that help is available - whether through medication, training, or a combination of approaches.